Nature Signaling Update News and reviews about the latest in cell signaling research, brought to you by Nature Publishing Group. http://www.signaling-gateway.org/update/ weekly 1 2003-06-20T20:00+00:00 Nature Signaling Update http://www.signaling-gateway.org/slices/logo_ucsd_sig.gif http://www.signaling-gateway.org/update/ Featured Article: Toll-like receptors: Less is more http://www.signaling-gateway.org/update/featured/ Proteolytic cleavage of the Toll-like receptor TLR9 creates a functional receptor that is retained at intracellular endolysosome compartments. Selected Update: Gene expression: Coming in waves http://www.signaling-gateway.org/update/updates/200811/nrm2535.html Transcription of calcineurin-responsive zinc-finger (Crz1) target genes is regulated by the frequency of rapid, synchronized bursts of Crz1 nuclear localization. Selected Update: Radiotherapy: Worming your way to cell death http://www.signaling-gateway.org/update/updates/200811/nrc2533.html Exposure to ionizing radiation stimulates the C. elegans p53-dependent and ceramide biosynthesis pathways to activate core mitochondrial apoptotic machinery. Selected Update: Immunology: An unexpected complement http://www.signaling-gateway.org/update/updates/200811/nrc2531.html The activation of complement signaling pathways in myeloid-derived suppressor cells (MDSCs) contributes to tumor growth by inhibiting the recruitment of tumor-infiltrating CD8+ T cells. Research Library: Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin http://www.nature.com/doifinder/10.1038/nature07451 Research Library: IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-kappaB as well as cell survival and oncogenesis http://www.nature.com/doifinder/10.1038/ncb1789 Research Library: High-speed, miniaturized fluorescence microscopy in freely moving mice http://www.nature.com/doifinder/10.1038/nmeth.1256 Nature Reviews Cancer Article Series: RB and E2F http://www.nature.com/nrc/series/RBandE2F/index.html The retinoblastoma (RB) tumor suppressor protein is famous for regulating the G1 phase of the cell cycle by suppressing the function of the E2F family of transcription factors. Nature Reviews Cancer has commissioned a short series of articles that discuss some of recent findings about RB function, including a FREE review entitled 'Cellular mechanisms of tumour suppression by the retinoblastoma gene' by Deborah L. Burkhart and Julien Sage.