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Research library: Techniques

2008: | December | November | October | September | August | July | June | May | April | March | February | January

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research
MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification
Jürgen Cox & Matthias Mann
Nature Biotechnology 26, 1367–1372
(December 2008); doi:10.1038/nbt.1511
| Summary | Full Text (HTML / PDF) |

article
Single-RNA counting reveals alternative modes of gene expression in yeast
Daniel Zenklusen, Daniel R Larson & Robert H Singer
Nature Structural & Molecular Biology 15, 1263–1271
(December 2008); doi:10.1038/nsmb.1514
| Summary | Full Text (HTML / PDF) |

article
Micropatterning for quantitative analysis of protein-protein interactions in living cells
Michaela Schwarzenbacher et al.
Nature Methods 5, 1053–1060
(December 2008); doi:10.1038/nmeth.1268
| Summary | Full Text (HTML / PDF) |

review
Fluorescent probes for super-resolution imaging in living cells
Marta Fernández-Suárez & Alice Y. Ting
Nature Reviews Molecular Cell Biology 9, 929–943
(December 2008); doi:10.1038/nrm2531
| Summary | Full Text (HTML / PDF) |

article
Whole-cell 3D STORM reveals interactions between cellular structures with nanometer-scale resolution
Bo Huang, Sara A Jones, Boerries Brandenburg & Xiaowei Zhuang
Nature Methods 5, 1047–1052
(December 2008); doi:10.1038/nmeth.1274
| Summary | Full Text (HTML / PDF) |

article
Epitope mapping of antibodies using bacterial surface display
Johan Rockberg, John Löfblom, Barbara Hjelm, Mathias Uhlén & Stefan Ståhl
Nature Methods 5, 1039–1045
(December 2008); doi:10.1038/nmeth.1272
| Summary | Full Text (HTML / PDF) |

news and views
On display on a bug: a systematic approach to characterize antibodies
Thomas Knorpp & Markus F Templin
Nature Methods 5, 1003–1004
(December 2008); doi:10.1038/nmeth1208-1003
| Full Text (HTML / PDF) |

article
A nano-positioning system for macromolecular structural analysis
Adam Muschielok et al.
Nature Methods 5, 965–971
(November 2008); doi:10.1038/nmeth.1259
| Summary | Full Text (HTML / PDF) |

review
Targeting and tinkering with interaction networks
Robert B Russell & Patrick Aloy
Nature Chemical Biology 4, 666–673
(November 2008); doi:10.1038/nchembio.119
| Summary | Full Text (HTML / PDF) |

brief communication
High-speed, miniaturized fluorescence microscopy in freely moving mice
Benjamin A Flusberg et al.
Nature Methods 5, 935–938
(November 2008); doi:10.1038/nmeth.1256
| Summary | Full Text (HTML / PDF) |

news and views
New views into the brain of mice on the move
Fritjof Helmchen & Carl C H Petersen
Nature Methods 5, 925–926
(November 2008); doi:10.1038/nmeth1108-925
| Full Text (HTML / PDF) |

commentary
Reverse engineering intracellular biochemical networks
Eli Zamir & Philippe I H Bastiaens
Nature Chemical Biology 4, 643–647
(November 2008); doi:10.1038/nchembio1108-643
| Summary | Full Text (HTML / PDF) |

article
Deconstructing voltage sensor function and pharmacology in sodium channels
Frank Bosmans, Marie-France Martin-Eauclaire & Kenton J. Swartz
Nature 456, 202–208
(13 November 2008); doi:10.1038/nature07473
| Summary | Full Text (HTML / PDF) |

news and views
Ion channels: The voltage-sensor quartet
J. R. Bankston & R. S. Kass
Nature 456, 183–185
(November 2008); doi:10.1038/456183a
| Full Text (HTML / PDF) |

research
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2
Danwei Huangfu et al.
Nature Biotechnology 26, 1269–1275
(November 2008); doi:10.1038/nbt.1502
| Summary | Full Text (HTML / PDF) |

news and views
The many ways to make an iPS cell
William E Lowry & Kathrin Plath
Nature Biotechnology 26, 1246–1248
(November 2008); doi:10.1038/nbt1108-1246
| Full Text (HTML / PDF) |

article
Accurate whole human genome sequencing using reversible terminator chemistry
David R. Bentley et al.
Nature 456, 53–59
(6 November 2008); doi:10.1038/nature07517
| Summary | Full Text (HTML / PDF) |

news and views
Human genetics: Individual genomes diversify
Samuel Levy & Robert L. Strausberg
Nature 456, 49–51
(November 2008); doi:10.1038/456049a
| Full Text (HTML / PDF) |

article
Decision tree–driven tandem mass spectrometry for shotgun proteomics
Danielle L Swaney, Graeme C McAlister & Joshua J Coon
Nature Methods 5, 959–964
(November 2008); doi:10.1038/nmeth.1260
| Summary | Full Text (HTML / PDF) |

review
Next-generation DNA sequencing
Jay Shendure & Hanlee Ji
Nature Biotechnology 26, 1135–1145
(October 2008); doi:10.1038/nbt1486
| Summary | Full Text (HTML / PDF) |

brief communication
Imaging individual mRNA molecules using multiple singly labeled probes
Arjun Raj, Patrick van den Bogaard, Scott A Rifkin, Alexander van Oudenaarden & Sanjay Tyagi
Nature Methods 5, 877–879
(October 2008); doi:10.1038/nmeth.1253
| Summary | Full Text (HTML / PDF) |

review
The potential and challenges of nanopore sequencing
Daniel Branton et al.
Nature Biotechnology 26 1146–1153
(October 2008); doi:10.1038/nbt.1495
| Summary | Full Text (HTML / PDF) |

article
Optogenetic analysis of synaptic function
Jana F Liewald et al.
Nature Methods 5, 895–902
(October 2008); doi:10.1038/nmeth.1252
| Summary | Full Text (HTML / PDF) |

article
Tracking the structural dynamics of proteins in solution using time-resolved wide-angle X-ray scattering
Marco Cammarata et al.
Nature Methods 5, 881–886
(October 2008); doi:10.1038/nmeth.1255
| Summary | Full Text (HTML / PDF) |

letter
FcRn-mediated antibody transport across epithelial cells revealed by electron tomography
Wanzhong He et al.
Nature 455, 542–546
(25 September 2008); doi:10.1038/nature07255
| Summary | Full Text (HTML / PDF) |

research
Predicting PDZ domain–peptide interactions from primary sequences
Jiunn R Chen, Bryan H Chang, John E Allen, Michael A Stiffler & Gavin MacBeath
Nature Biotechnology 26, 1041–1045
(September 2008); doi:10.1038/nbt.1489
| Summary | Full Text (HTML / PDF) |

article
Single-spike detection in vitro and in vivo with a genetic Ca2+ sensor
Damian J Wallace et al.
Nature Methods 5, 797–804
(September 2008); doi:10.1038/nmeth.1242
| Summary | Full Text (HTML / PDF) |

article
A genetically encoded calcium indicator for chronic in vivo two-photon imaging
Marco Mank et al.
Nature Methods 5, 805–811
(September 2008); doi:10.1038/nmeth.1243
| Summary | Full Text (HTML / PDF) |

news and views
Genetically encoded Ca2+ sensors come of age
Nathalie L Rochefort & Arthur Konnerth
Nature Methods 5, 761–762
(September 2008); doi:10.1038/nmeth0908-761
| Full Text (HTML / PDF) |

article
Imaging dynamic cell-cell junctional coupling in vivo using Trojan-LAMP
Yan-Ming Guo et al.
Nature Methods 5, 835–841
(September 2008); doi:10.1038/nmeth.1238
| Summary | Full Text (HTML / PDF) |

letter
Photoswitchable fluorescent proteins enable monochromatic multilabel imaging and dual color fluorescence nanoscopy
Martin Andresen et al.
Nature Biotechnology 26, 1035–1040
(September 2008); doi:10.1038/nbt.1493
| Summary | Full Text (HTML / PDF) |

article
Genome-wide analysis of transcription factor binding sites based on ChIP-Seq data
Anton Valouev et al.
Nature Methods 5, 829–834
(September 2008); doi:10.1038/nmeth.1246
| Summary | Full Text (HTML / PDF) |

article
High-throughput, quantitative analyses of genetic interactions in E. coli
Athanasios Typas et al.
Nature Methods 5, 781–787
(September 2008); doi:10.1038/nmeth.1240
| Summary | Full Text (HTML / PDF) |

article
eSGA: E. coli synthetic genetic array analysis
Gareth Butland et al.
Nature Methods 5, 789–795
(September 2008); doi:10.1038/nmeth.1239
| Summary | Full Text (HTML / PDF) |

news and views
Sex to the rescue
Thomas J Silhavy & Zemer Gitai
Nature Methods 5, 759–760
(September 2008); doi:10.1038/nmeth0908-759
| Full Text (HTML / PDF) |

article
Dynamic multiple-target tracing to probe spatiotemporal cartography of cell membranes
Arnauld Sergé, Nicolas Bertaux, Hervé Rigneault & Didier Marguet
Nature Methods 5, 687–694
(August 2008); doi:10.1038/nmeth.1233
| Summary | Full Text (HTML / PDF) |

perspective
Neutralizing antibodies to therapeutic enzymes: considerations for testing, prevention and treatment
Jinhai Wang et al.
Nature Biotechnology 26, 901–908
(August 2008); doi:10.1038/nbt.1484
| Summary | Full Text (HTML / PDF) |

article
Site-specific conjugation of a cytotoxic drug to an antibody improves the therapeutic index
Jagath R Junutula et al.
Nature Biotechnology 26, 925–932
doi:10.1038/nbt.1480
| Summary | Full Text (HTML / PDF) |

news and views
Antibody-drug conjugates ace the tolerability test
Nitin K Damle
Nature Biotechnology 26, 884–885
(August 2008); doi:10.1038/nbt0808-884
| Full Text (HTML / PDF) |

article
A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types
Marius Wernig et al.
Nature Biotechnology 26, 916–924
(August 2008); doi:10.1038/nbt1483
| Summary | Full Text (HTML / PDF) |

article
Detection of heteromerization of more than two proteins by sequential BRET–FRET
Paulina Carriba et al.
Nature Methods 5, 727–733
(August 2008); doi:10.1038/nmeth.1229
| Summary | Full Text (HTML / PDF) |

article
Robust single-particle tracking in live-cell time-lapse sequences
Khuloud Jaqaman et al.
Nature Methods 5, 695–702
(August 2008); doi:10.1038/nmeth.1237
| Summary | Full Text (HTML / PDF) |

news and views
Single-particle tracking: connecting the dots
Michael J Saxton
Nature Methods 5, 671–672
(August 2008); doi:10.1038/nmeth0808-671
| Full Text (HTML / PDF) |

review
The art and design of genetic screens: RNA interference
Michael Boutros & Julie Ahringer
Nature Reviews Genetics 9, 554–566
(July 2008); doi:10.1038/nrg2364
| Summary | Full Text (HTML / PDF) |

review
Molecular imaging in drug development
Jürgen K. Willmann, Nicholas van Bruggen, Ludger M. Dinkelborg & Sanjiv S. Gambhir
Nature Reviews Drug Discovery 7, 591–607
(July 2008); doi:10.1038/nrd2290
| Summary | Full Text (HTML / PDF) |

article
Functional immobilization of signaling proteins enables control of stem cell fate
Kristin Alberti et al.
Nature Methods 5, 645–650
(July 2008); doi:10.1038/nmeth.1222
| Summary | Full Text (HTML / PDF) |

brief communication
In vitro whole-organ imaging: 4D quantification of growing mouse limb buds
Marit J Boot et al.
Nature Methods 5, 609–612
(July 2008); doi:10.1038/nmeth.1219
| Summary | Full Text (HTML / PDF) |

article
Automated on-chip rapid microscopy, phenotyping and sorting of C. elegans
Kwanghun Chung, Matthew M Crane & Hang Lu
Nature Methods 5, 637–643
(July 2008); doi:10.1038/nmeth.1227
| Summary | Full Text (HTML / PDF) |

news and views
Microfluidics: streamlining discovery in worm biology
S Elizabeth Hulme, Sergey S Shevkoplyas & Aravinthan Samuel
Nature Methods 5, 589–590
(July 2008); doi:10.1038/nmeth0708-589
| Full Text (HTML / PDF) |

article
Mapping and quantifying mammalian transcriptomes by RNA-Seq
Ali Mortazavi, Brian A Williams, Kenneth McCue, Lorian Schaeffer & Barbara Wold
Nature Methods 5, 621–628
(July 2008); doi:10.1038/nmeth.1226
| Summary | Full Text (HTML / PDF) |

news and views
The beginning of the end for microarrays?
Jay Shendure
Nature Methods 5, 585–587
(July 2008); doi:10.1038/nmeth0708-585
| Full Text (HTML / PDF) |

brief communication
Lifeact: a versatile marker to visualize F-actin
Julia Riedl et al.
Nature Methods 5, 605–607
(July 2008); doi:10.1038/nmeth.1220
| Summary | Full Text (HTML / PDF) |

letter
Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient
Brian G. Fuller et al.
Nature 453, 1132–1136
(19 June 2008); doi:10.1038/nature06923
| Summary | Full Text (HTML / PDF) |

article
Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites
Oliver Schilling & Christopher M Overall
Nature Biotechnology 26, 685–694
(June 2008); doi:10.1038/nbt1408
| Summary | Full Text (HTML / PDF) |

news and views
Proteases' prime targets revealed
Scott L Diamond & Doron Greenbaum
Nature Biotechnology 26, 652–653
(June 2008); doi:10.1038/nbt0608-652
| Summary | Full Text (HTML / PDF) |

article
Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization
Damien Maurel et al.
Nature Methods 5, 561–567
(June 2008); doi:10.1038/nmeth.1213
| Summary | Full Text (HTML / PDF) |

letter
Chemically ubiquitylated histone H2B stimulates hDot1L-mediated intranucleosomal methylation
Robert K. McGinty, Jaehoon Kim, Champak Chatterjee, Robert G. Roeder & Tom W. Muir
Nature 453, 812–816
(5 June 2008); doi:10.1038/nature06906
| Summary | Full Text (HTML / PDF) |

article
Real-time imaging of the intracellular glutathione redox potential
Marcus Gutscher et al.
Nature Methods 5, 553–559
(June 2008); doi:10.1038/nmeth.1212
| Summary | Full Text (HTML / PDF) |

letter
The impact of target site accessibility on the design of effective siRNAs
Hakim Tafer et al.
Nature Biotechnology 26, 578–583
(May 2008); doi:10.1038/nbt1404
| Summary | Full Text (HTML / PDF) |

article
Spheroid-based engineering of a human vasculature in mice
Abdullah Alajati et al.
Nature Methods 5, 439–445
(May 2008); doi:10.1038/nmeth.1198
| Summary | Full Text (HTML / PDF) |

article
Modeling lymphangiogenesis in a three-dimensional culture system
Françoise Bruyère et al.
Nature Methods 5, 431–437
(May 2008); doi:10.1038/nmeth.1205
| Summary | Full Text (HTML / PDF) |

news and views
Metastasis: two assays explore the two roads traveled
Diane Renee Bielenberg
Nature Methods 5, 384–385
(May 2008); doi:10.1038/nmeth0508-384
| Summary | Full Text (HTML / PDF) |

article
Live-cell photoactivated localization microscopy of nanoscale adhesion dynamics
Hari Shroff, Catherine G Galbraith, James A Galbraith & Eric Betzig
Nature Methods 5, 417–423
(May 2008); doi:10.1038/nmeth.1202
| Summary | Full Text (HTML / PDF) |

news and views
Super-resolution light microscopy goes live
Mats G L Gustafsson
Nature Methods 5, 385–387
(May 2008); doi:10.1038/nmeth0508-385
| Summary | Full Text (HTML / PDF) |

article
Kemp elimination catalysts by computational enzyme design
Daniela Röthlisberger et al.
Nature 453, 190–195
(8 May 2008); doi:10.1038/nature06879
| Summary | Full Text (HTML / PDF) |

news and views
Computational biochemistry: Old enzymes, new tricks
Giovanna Ghirlanda
Nature 453, 164–166
(8 May 2008); doi:10.1038/453164a
| Full Text (HTML / PDF) |

article
BAC TransgeneOmics: a high-throughput method for exploration of protein function in mammals
Ina Poser et al.
Nature Methods 5, 409–415
(May 2008); doi:10.1038/nmeth.1199
| Summary | Full Text (HTML / PDF) |

article
BAC to the future: functional genomics in mammals
Assen Roguev & Nevan J Krogan
Nature Methods 5, 383–384
(May 2008); doi:10.1038/nmeth0508-383
| Summary | Full Text (HTML / PDF) |

article
MicroRNAs accurately identify cancer tissue origin
Nitzan Rosenfeld et al.
Nature Biotechnology 26, 462–469
(April 2008); doi:10.1038/nbt1392
| Summary | Full Text (HTML / PDF) |

news and views
Cancer biomarker profiling with microRNAs
Stefanie S Jeffrey
Nature Biotechnology 26, 400–401
(April 2008); doi:10.1038/nbt0408-400
| Summary | Full Text (HTML / PDF) |

brief communication
Genetic control of neuronal activity in mice conditionally expressing TRPV1
Benjamin R Arenkiel, Marguerita E Klein, Ian G Davison, Lawrence C Katz & Michael D Ehlers
Nature Methods 5, 299–302
(April 2008); doi:10.1038/nmeth.1190
| Summary | Full Text (HTML / PDF) |

news and views
Expanding the toolbox for remote control of neuronal circuits
Thomas Knöpfel
Nature Methods 5, 293–295
(April 2008); doi:10.1038/nmeth0408-293
| Summary | Full Text (HTML / PDF) |

letter
LNA-mediated microRNA silencing in non-human primates
Joacim Elmén et al.
Nature 452, 896–899
(17 April 2008); doi:10.1038/nature06783
| Summary | Full Text (HTML / PDF) |

article
Photochemical control of endogenous ion channels and cellular excitability
Doris L Fortin et al.
Nature Methods 5, 331–338
(April 2008); doi:10.1038/nmeth.1187
| Summary | Full Text (HTML / PDF) |

brief communication
A quantitative analysis software tool for mass spectrometry-based proteomics
Sung Kyu Park, John D Venable, Tao Xu & John R Yates III
Nature Methods 5, 319–322
(April 2008); doi:10.1038/nmeth.1195
| Summary | Full Text (HTML / PDF) |

review
Imaging in the era of molecular oncology
Ralph Weissleder & Mikael J. Pittet
Nature 452, 580–589
(3 April 2008); doi:10.1038/nature06917
| Summary | Full Text (HTML / PDF) |

article
Pore-opening mechanism of the nicotinic acetylcholine receptor evinced by proton transfer
Gisela D Cymes & Claudio Grosman
Nature Structural & Molecular Biology 15, 389–396
(April 2008); doi:10.1038/nsmb.1407
| Summary | Full Text (HTML / PDF) |

article
Direct measurement of protein dynamics inside cells using a rationally designed photoconvertible protein
Tomoki Matsuda, Atsushi Miyawaki & Takeharu Nagai
Nature Methods 5, 339–345
(April 2008); doi:10.1038/nmeth.1193
| Summary | Full Text (HTML / PDF) |

article
Homogeneous reporter system enables quantitative functional assessment of multiple transcription factors
Sergei Romanov et al.
Nature Methods 5, 253–260
(March 2008); doi:10.1038/nmeth.1186
| Summary | Full Text (HTML / PDF) |

review
Synthetic fluorescent sensors for studying the cell biology of metals
Dylan W Domaille, Emily L Que & Christopher J Chang
Nature Chemical Biology 4, 168–175
(March 2008); doi:10.1038/nchembio.69
| Summary | Full Text (HTML / PDF) |

resources
Large-scale chemical dissection of mitochondrial function
Bridget K Wagner et al.
Nature Biotechnology 26, 343–351
(March 2008); doi:10.1038/nbt1387
| Summary | Full Text (HTML / PDF) |

news and views
A toolkit for the cell's powerhouse
Eric A Schon
Nature Biotechnology 26, 294–296
(March 2008); doi:10.1038/nbt0308-294
| Summary | Full Text (HTML / PDF) |

review
Synthetic fluorescent sensors for studying the cell biology of metals
Dylan W Domaille, Emily L Que & Christopher J Chang
Nature Chemical Biology 4, 168–175
(March 2008); doi:10.1038/nchembio.69
| Summary | Full Text (HTML / PDF) |

brief communication
Generating somatic mosaicism with a Cre recombinase–microsatellite sequence transgene
Aytekin Akyol, Takao Hinoi, Ying Feng, Guido T Bommer, Thomas M Glaser & Eric R Fearon
Nature Methods 5, 231–233
(March 2008); doi:10.1038/nmeth.1182
| Summary | Full Text (HTML / PDF) |

news and views
Harnessing mismatch repair to model sporadic cancers
Richard Fishel & Joanna Groden
Nature Methods 5, 225–226
(March 2008); doi:10.1038/nmeth0308-225
| Summary | Full Text (HTML / PDF) |

brief communication
A secreted luciferase for ex vivo monitoring of in vivo processes
Thomas Wurdinger et al.
Nature Methods 5, 171–173
(February 2008); doi:10.1038/nmeth.1177
| Summary | Full Text (HTML / PDF) |

letter
Fluorogen-activating single-chain antibodies for imaging cell surface proteins
Christopher Szent-Gyorgyi et al.
Nature Biotechnology 26, 235–240
(February 2008); doi:10.1038/nbt1368
| Summary | Full Text (HTML / PDF) |

brief communication
Epitope tagging of endogenous proteins for genome-wide ChIP-chip studies
Xiaodong Zhang et al.
Nature Methods 5, 163–165
(February 2008); doi:10.1038/nmeth1170
| Summary | Full Text (HTML / PDF) |

review
New approaches for imaging tumour responses to treatment
Kevin Brindle
Nature Reviews Cancer 8, 94–107
(February 2008); doi:10.1038/nrc2289
| Summary | Full Text (HTML / PDF) |

review
Protein production and purification
Structural Genomics Consortium et al.
Nature Methods 5, 135–146
(February 2008); doi:10.1038/nmeth.f.202
| Summary | Full Text (HTML / PDF) |

brief communication
Switching constant domains enhances agonist activities of antibodies to a thrombopoietin receptor
Masayuki Kai et al.
Nature Biotechnology 26, 209–211
(February 2008); doi:10.1038/nbt1376
| Summary | Full Text (HTML / PDF) |

article
High-content single-cell drug screening with phosphospecific flow cytometry
Peter O Krutzik, Janelle M Crane, Matthew R Clutter & Garry P Nolan
Nature Chemical Biology 4, 132–142
(February 2008); doi:10.1038/nchembio.2007.59
| Summary | Full Text (HTML / PDF) |

brief communication
High-density mapping of single-molecule trajectories with photoactivated localization microscopy
Suliana Manley et al.
Nature Methods 5, 155–157
(February 2008); doi:10.1038/nmeth.1176
| Summary | Full Text (HTML / PDF) |

brief communication
Highly inclined thin illumination enables clear single-molecule imaging in cells
Makio Tokunaga, Naoko Imamoto & Kumiko Sakata-Sogawa
Nature Methods 5, 159–161
(February 2008); doi:10.1038/nmeth1171
| Summary | Full Text (HTML / PDF) |

news and views
How the sum of its parts gets greater than the whole
Mario Brameshuber & Gerhard J Schütz
Nature Methods 5, 133–134
(February 2008); doi:10.1038/nmeth0208-133
| Summary | Full Text (HTML / PDF) |

letter
Generation of induced pluripotent stem cells without Myc from mouse and human fibroblasts
Masato Nakagawa et al.
Nature Biotechnology 26, 101–106
(January 2008); doi:10.1038/nbt1374
| Summary | Full Text (HTML / PDF) |

news and views
Simpler and safer cell reprogramming
Martin F Pera & Kouichi Hasegawa
Nature Biotechnology 26, 59–60
(January 2008); doi:10.1038/nbt0108-59
| Summary | Full Text (HTML / PDF) |

article
Tracking transmitter-gated P2X cation channel activation in vitro and in vivo
Esther Richler et al.
Nature Methods 5, 87–93
(January 2008); doi:10.1038/nmeth1144
| Summary | Full Text (HTML / PDF) |

article
CD19 is essential for B cell activation by promoting B cell receptor–antigen microcluster formation in response to membrane-bound ligand
David Depoil et al.
Nature Immunology 9, 63–72
(January 2008); doi:10.1038/ni1547
| Summary | Full Text (HTML / PDF) |

review
Live-cell imaging of cAMP dynamics
Debbie Willoughby & Dermot M F Cooper
Nature Methods 5, 29–36
(January 2008); doi:10.1038/nmeth1135
| Summary | Full Text (HTML / PDF) |

article
Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism
Paul B Yu et al.
Nature Chemical Biology 4, 33–41
(January 2008); doi:10.1038/nchembio.2007.54
| Summary | Full Text (HTML / PDF) |

news and views
Small-molecule dissection of BMP signaling
Gregory J Anderson & Deepak Darshan
Nature Chemical Biology 4, 15–16
(January 2008); doi:10.1038/nchembio0108-15
| Full Text (HTML / PDF) |

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