Research library: Kinases
2008:
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December
letter
MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts
Thomas Thum et al.
Nature 456, 980–984
(18 December 2008); doi:10.1038/nature07511
| Summary | Full Text (HTML / PDF) |
letter
Activation of TGF-β/activin signalling resets the circadian clock through rapid induction of Dec1 transcripts
Naohiro Kon et al.
Nature Cell Biology 10, 1463–1469
(December 2008); doi:10.1038/ncb1806
| Summary | Full Text (HTML / PDF) |
article
FGF acts as a co-transmitter through adenosine A2A receptor to regulate synaptic plasticity
Marc Flajolet et al.
Nature Neuroscience 11, 1402–1409
(December 2008); doi:10.1038/nn.2216
| Summary | Full Text (HTML / PDF) |
article
Negative feedback that improves information transmission in yeast signalling
Richard C. Yu et al.
Nature 456, 755–761
(11 December 2008); doi:10.1038/nature07513
| Summary | Full Text (HTML / PDF) |
article
GABAB receptor activation mediates frequency-dependent plasticity of developing GABAergic synapses
Chun Xu, Man-xia Zhao, Mu-ming Poo & Xiao-hui Zhang
Nature Neuroscience 11, 1410–1418
(December 2008); doi:10.1038/nn.2215
| Summary | Full Text (HTML / PDF) |
Correspondence
PhosphoPep—a database of protein phosphorylation sites in model organisms
Bernd Bodenmiller et al.
Nature Biotechnology 26, 1339–1340
(December 2008); doi:10.1038/nbt1208-1339
| Summary | Full Text (HTML / PDF) |
letter
X-linked and cellular IAPs modulate the stability of C-RAF kinase and cell motility
Taner Dogan et al.
Nature Cell Biology 10, 1447–1455
(December 2008); doi:10.1038/ncb1804
| Summary | Full Text (HTML / PDF) |
November
letter
Scaffolding function of PAK in the PDK1–Akt pathway
Maiko Higuchi, Keisuke Onishi, Chikako Kikuchi & Yukiko Gotoh
Nature Cell Biology 10, 1356–1364
(November 2008); doi:10.1038/ncb1795
| Summary | Full Text (HTML / PDF) |
article
Structure and function of a transcriptional network activated by the MAPK Hog1
Andrew P Capaldi et al.
Nature Genetics 40, 1300–1306
(November 2008); doi:10.1038/ng.235
| Summary | Full Text (HTML / PDF) |
article
Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif
Kotaro Shirakawa et al.
Nature Structural & Molecular Biology 15, 1184–1191
(November 2008); doi:10.1038/nsmb.1497
| Summary | Full Text (HTML / PDF) |
letter
Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways
Kyoko Arimoto, Hiroyuki Fukuda, Shinobu Imajoh-Ohmi, Haruo Saito & Mutsuhiro Takekawa
Nature Cell Biology 10, 1324–1332
(November 2008); doi:10.1038/ncb1791
| Summary | Full Text (HTML / PDF) |
article
FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway
Masamichi Ishiai et al.
Nature Structural & Molecular Biology 15, 1138–1146
(November 2008); doi:10.1038/nsmb.1504
| Summary | Full Text (HTML / PDF) |
news and views
A major switch for the Fanconi anemia DNA damage–response pathway
Weidong Wang
Nature Structural & Molecular Biology 15, 1128–1130
(November 2008); doi:10.1038/nsmb1108-1128
| Full Text (HTML / PDF) |
article
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
Beth Apsel et al.
Nature Chemical Biology 4, 691–699
(November 2008); doi:10.1038/nchembio.117
| Summary | Full Text (HTML / PDF) |
news and views
Killing two kinase families with one stone
Benoit Bilanges, Neil Torbett & Bart Vanhaesebroeck
Nature Chemical Biology 4, 648–649
(November 2008); doi:10.1038/nchembio1108-648
| Full Text (HTML / PDF) |
perspective
Cyclin-dependent kinases and cell-cycle transitions: does one fit all?
Helfrid Hochegger, Shunichi Takeda & Tim Hunt
Nature Reviews Molecular Cell Biology 9, 910–916
(November 2008); doi:10.1038/nrm2510
| Summary | Full Text (HTML / PDF) |
review
New regulators of NF-κB in inflammation
Sankar Ghosh & Matthew S. Hayden
Nature Reviews Immunology 8, 837–848
(November 2008); doi:10.1038/nri2423
| Summary | Full Text (HTML / PDF) |
October
article
Glycogen synthase kinase 3 in MLL leukaemia maintenance and targeted therapy
Zhong Wang, Kevin S. Smith, Mark Murphy, Obdulio Piloto, Tim C. P. Somervaille & Michael L. Cleary
Nature 455, 1205–1209
(30 October 2008); doi:10.1038/nature07284
| Summary | Full Text (HTML / PDF) |
article
Activation of tyrosine kinases by mutation of the gatekeeper threonine
Mohammad Azam, Markus A Seeliger, Nathanael S Gray, John Kuriyan & George Q Daley
Nature Structural & Molecular Biology 15, 1109–1118
(October 2008); doi:10.1038/nsmb.1486
| Summary | Full Text (HTML / PDF) |
review
IKKα, a critical regulator of epidermal differentiation and a suppressor of skin cancer
Pascal Descargues, Alok K Sil and Michael Karin
The EMBO Journal 27, 2639–2647
(October 2008); doi:10.1038/emboj2008196a
| Summary | Full Text (HTML / PDF) |
article
Identification of ALK as a major familial neuroblastoma predisposition gene
Yaël P. Mossé et al.
Nature 455, 930–935
(16 October 2008); doi:10.1038/nature07261
| Summary | Full Text (HTML / PDF) |
letter
Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma
Isabelle Janoueix-Lerosey et al.
Nature 455, 967–970
(16 October 2008); doi:10.1038/nature07398
| Summary | Full Text (HTML / PDF) |
letter
Oncogenic mutations of ALK kinase in neuroblastoma
Yuyan Chen et al.
Nature 455, 971–974
(16 October 2008); doi:10.1038/nature07399
| Summary | Full Text (HTML / PDF) |
letter
Activating mutations in ALK provide a therapeutic target in neuroblastoma
Rani E. George et al.
Nature 455, 975–978
(16 October 2008); doi:10.1038/nature07397
| Summary | Full Text (HTML / PDF) |
news and views
Cancer: A ringleader identified
Charis Eng
Nature 455, 883–884
(16 October 2008); doi:10.1038/455883a
| Full Text (HTML / PDF) |
article
Toll-like receptor—mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway
Weiping Cao et al.
Nature Immunology 9, 1157–1164
(October 2008); doi:10.1038/ni.1645
| Summary | Full Text (HTML / PDF) |
news and views
RAPping production of type I interferon in pDCs through mTOR
Mauro Costa-Mattioli & Nahum Sonenberg
Nature Immunology 9, 1097–1099
(October 2008); doi:10.1038/ni1008-1097
| Full Text (HTML / PDF) |
brief communication
ERK-dependent PSD-95 induction in the gustatory cortex is necessary for taste learning, but not retrieval
Alina Elkobi, Ingrid Ehrlich, Katya Belelovsky, Liza Barki-Harrington & Kobi Rosenblum
Nature Neuroscience 11, 1149–1151
(October 2008); doi:10.1038/nn.2190
| Summary | Full Text (HTML / PDF) |
article
Plasticity of the PAS domain and a potential role for signal transduction in the histidine kinase DcuS
Manuel Etzkorn et al.
Nature Structural & Molecular Biology 15, 1031–1039
(October 2008); doi:10.1038/nsmb.1493
| Summary | Full Text (HTML / PDF) |
letter
CDK targets Sae2 to control DNA-end resection and homologous recombination
Pablo Huertas, Felipe Cortés-Ledesma, Alessandro A. Sartori, Andrés Aguilera & Stephen P. Jackson
Nature 455, 689–692
(2 October 2008); doi:10.1038/nature07215
| Summary | Full Text (HTML / PDF) |
review
The RSK family of kinases: emerging roles in cellular signalling
Rana Anjum & John Blenis
Nature Reviews Molecular Cell Biology 9, 747–758
(October 2008); doi:10.1038/nrm2509
| Summary | Full Text (HTML / PDF) |
September
letter
Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression
Zheng Fu et al.
Nature Cell Biology 10, 1076–1082
(25 September 2008); doi:10.1038/ncb1767
| Summary | Full Text (HTML / PDF) |
article
The kinase p38α serves cell type—specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression
Chun Kim et al.
Nature Immunology 9, 1019–1027
(September 2008); doi:10.1038/ni.1640
| Summary | Full Text (HTML / PDF) |
letter
Brain-type creatine kinase has a crucial role in osteoclast-mediated bone resorption
Eun-Ju Chang et al.
Nature Medicine 14, 966–972
(September 2008); doi:10.1038/nm.1860
| Summary | Full Text (HTML / PDF) |
article
Raft nanodomains contribute to Akt/PKB plasma membrane recruitment and activation
Rémi Lasserre et al.
Nature Chemical Biology 4, 538–547
(September 2008); doi:10.1038/nchembio.103
| Summary | Full Text (HTML / PDF) |
letter
Platelet-derived growth factor-α receptor activation is required for human cytomegalovirus infection
Liliana Soroceanu, Armin Akhavan & Charles S. Cobbs
Nature 455, 391–395
(18 September 2008); doi:10.1038/nature07209
| Summary | Full Text (HTML / PDF) |
letter
Polo-like kinase-1 is activated by aurora A to promote checkpoint recovery
Libor Macůrek et al.
Nature 455, 119–123
(04 September 2008); doi:10.1038/nature07185
| Summary | Full Text (HTML / PDF) |
article
The kinases MSK1 and MSK2 act as negative regulators of Toll-like receptor signaling
Olga Ananieva et al.
Nature Immunology 9, 1028–1036
(September 2008); doi:10.1038/ni.1644
| Summary | Full Text (HTML / PDF) |
progress
Structural comparisons of class I phosphoinositide 3-kinases
L. Mario Amzel et al.
Nature Reviews Cancer 8, 665–669
(September 2008); doi:10.1038/nrc2443
| Summary | Full Text (HTML / PDF) |
article
Serine phosphorylation of ephrinB2 regulates trafficking of synaptic AMPA receptors
Clara L Essmann et al.
Nature Neuroscience 11, 1035–1043
(September 2008); doi:10.1038/nn.2171
| Summary | Full Text (HTML / PDF) |
article
Circadian oscillation of hippocampal MAPK activity and cAMP: implications for memory persistence
Kristin L Eckel-Mahan et al.
Nature Neuroscience 11, 1074–1082
(September 2008); doi:10.1038/nn.2174
| Summary | Full Text (HTML / PDF) |
news and views
Rhythms of memory
Tania L Roth & J David Sweatt
Nature Neuroscience 11, 993–994
(September 2008); doi:10.1038/nn0908-993
| Full Text (HTML / PDF) |
August
article
The regulated assembly of a PKCε complex controls the completion of cytokinesis
Adrian T. Saurin et al.
Nature Cell Biology 10, 891–901
(August 2008); doi:10.1038/ncb1749
| Summary | Full Text (HTML / PDF) |
letter
IQGAP3 regulates cell proliferation through the Ras/ERK signalling cascade
Hisashi Nojima et al.
Nature Cell Biology 10, 971–978
(August 2008); doi:10.1038/ncb1757
| Summary | Full Text (HTML / PDF) |
article
Nonmuscle myosin light-chain kinase mediates neutrophil transmigration in sepsis-induced lung inflammation by activating β2 integrins
Jingsong Xu et al.
Nature Immunology 9, 880–886
(August 2008); doi:10.1038/ni.1628
| Summary | Full Text (HTML / PDF) |
letter
Reversal of learning deficits in a Tsc2+/− mouse model of tuberous sclerosis
Dan Ehninger et al.
Nature Medicine 14, 843–848
doi:10.1038/nm1788
| Summary | Full Text (HTML / PDF) |
article
Cell type–specific regulation of DARPP-32 phosphorylation by psychostimulant and antipsychotic drugs
Helen S Bateup et al.
Nature Neuroscience 11, 932–939
(August 2008); doi:10.1038/nn.2153
| Summary | Full Text (HTML / PDF) |
article
PICK1 uncoupling from mGluR7a causes absence-like seizures
Federica Bertaso et al.
Nature Neuroscience 11, 940–948
(August 2008); doi:10.1038/nn.2142
| Summary | Full Text (HTML / PDF) |
article
The DEAD-box helicase DDX3X is a critical component of the TANK-binding kinase 1-dependent innate immune response
Didier Soulat et al.
The EMBO Journal 27, 2135–2146
(August 2008); doi:10.1038/emboj.2008.126
| Summary | Full Text (HTML / PDF) |
letter
cAMP signalling in mushroom bodies modulates temperature preference behaviour in Drosophila
Sung-Tae Hong et al.
Nature 454, 771–775
(7 August 2008); doi:10.1038/nature07090
| Summary | Full Text (HTML / PDF) |
letter
Essential roles of PI(3)K–p110β in cell growth, metabolism and tumorigenesis
Shidong Jia et al.
Nature 454, 776–779
(7 August 2008); doi:10.1038/nature07091
| Summary | Full Text (HTML / PDF) |
letter
Crystal structure of the neurotrophin-3 and p75NTR symmetrical complex
Yong Gong, Peng Cao, Hong-jun Yu & Tao Jiang
Nature 454, 789–793
(7 August 2008); doi:10.1038/nature07089
| Summary | Full Text (HTML / PDF) |
article
A traffic-activated Golgi-based signalling circuit coordinates the secretory pathway
Teodoro Pulvirenti et al.
Nature Cell Biology 10, 912–922
(August 2008); doi:10.1038/ncb1751
| Summary | Full Text (HTML / PDF) |
news and views
Golgi gets wired up
Lennart Asp & Tommy Nilsson
Nature Cell Biology 10, 885–887
(August 2008); doi:10.1038/ncb0808-885
| Full Text (HTML / PDF) |
review
ATR: an essential regulator of genome integrity
Karlene A. Cimprich & David Cortez
Nature Reviews Molecular Cell Biology 9, 616–627
(August 2008); doi:10.1038/nrm2450
| Summary | Full Text (HTML / PDF) |
July
letter
Saccharomyces cerevisiae ATM orthologue suppresses break-induced chromosome translocations
Kihoon Lee, Yu Zhang & Sang Eun Lee
Nature 454, 543–546
(24 July 2008); doi:10.1038/nature07054
| Summary | Full Text (HTML / PDF) |
article
Positive feedback of G1 cyclins ensures coherent cell cycle entry
Jan M. Skotheim, Stefano Di Talia, Eric D. Siggia & Frederick R. Cross
Nature 454, 291–296
(17 July 2008); doi:10.1038/nature07118
| Summary | Full Text (HTML / PDF) |
letter
Positive feedback sharpens the anaphase switch
Liam J. Holt, Andrew N. Krutchinsky & David O. Morgan
Nature 454, 353–357
(17 July 2008); doi:10.1038/nature07050
| Summary | Full Text (HTML / PDF) |
news and views
Systems biology: On the cell cycle and its switches
Silvia D. M. Santos & James E. Ferrell
Nature 454, 288–289
(17 July 2008); doi:10.1038/454288a
| Full Text (HTML / PDF) |
article
Control of HIPK2 stability by ubiquitin ligase Siah-1 and checkpoint kinases ATM and ATR
Melanie Winter et al.
Nature Cell Biology 10, 812–824
(July 2008); doi:10.1038/ncb1743
| Summary | Full Text (HTML / PDF) |
review
Colony-stimulating factors in inflammation and autoimmunity
John A. Hamilton
Nature Reviews Immunology 8, 533–544
(July 2008); doi:10.1038/nri2356
| Summary | Full Text (HTML / PDF) |
scientific report
Drosophila RalA is essential for the maintenance of Jak/Stat signalling in ovarian follicles
Christian Ghiglione, Olivier Devergne, Delphine Cerezo & Stéphane Noselli
EMBO reports 9, 676–682
doi:10.1038/embor.2008.79
| Summary | Full Text (HTML / PDF) |
June
letter
Analysis of a spatial orientation memory in Drosophila
Kirsa Neuser, Tilman Triphan, Markus Mronz, Burkhard Poeck & Roland Strauss
Nature 453, 1244–1247
(26 June 2008); doi:10.1038/nature07003
| Summary | Full Text (HTML / PDF) |
news and views
Behavioural neuroscience: Out of sight, but not out of mind
Seth M. Tomchik & Ronald L. Davis
Nature 453, 1192–1194
(26 June 2008); doi:10.1038/4531192a
| Full Text (HTML / PDF) |
article
Inactivation of Cdh1 by synergistic action of Cdk1 and polo kinase is necessary for proper assembly of the mitotic spindle
Karen Crasta, Hong Hwa Lim, Thomas H. Giddings, Jr, Mark Winey & Uttam Surana
Nature Cell Biology 10, 665–675
doi:10.1038/ncb1729
| Summary | Full Text (HTML / PDF) |
letter
The anaplastic lymphoma kinase is an effective oncoantigen for lymphoma vaccination
Roberto Chiarle et al.
Nature Medicine 14, 676–680
(June 2008); doi:10.1038/nm1769
| Summary | Full Text (HTML / PDF) |
letter
Midzone activation of aurora B in anaphase produces an intracellular phosphorylation gradient
Brian G. Fuller et al.
Nature 453, 1132–1136
(19 June 2008); doi:10.1038/nature06923
| Summary | Full Text (HTML / PDF) |
letter
p53-Driven apoptosis limits centrosome amplification and genomic instability downstream of NPM1 phosphorylation
Maria Emanuela Cuomo et al.
Nature Cell Biology 10, 723–730
(June 2008); doi:10.1038/ncb1735
| Summary | Full Text (HTML / PDF) |
article
The receptor tyrosine kinase Flt3 is required for dendritic cell development in peripheral lymphoid tissues
Claudia Waskow et al.
Nature Immunology 9, 676–683
(June 2008); doi:10.1038/ni.1615
| Summary | Full Text (HTML / PDF) |
news and views
Homeostasis of dendritic cell pool in lymphoid organs
Cedric Auffray, Yalin Emre & Frederic Geissmann
Nature Immunology 9, 584–586
(June 2008); doi:10.1038/ni0608-584
| Full Text (HTML / PDF) |
article
Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility
Nobutaka Kato et al.
Nature Chemical Biology 4, 347–356
(June 2008); doi:10.1038/nchembio.87
| Summary | Full Text (HTML / PDF) |
news and views
Stopping malaria parasites dead in their tracks
Christian D Doerig
Nature Chemical Biology 4, 334–335
(June 2008); doi:10.1038/nchembio0608-3340
| Full Text (HTML / PDF) |
letter
Draper-dependent glial phagocytic activity is mediated by Src and Syk family kinase signalling
Jennifer S. Ziegenfuss et al.
Nature 453, 935–939
(12 June 2008); doi:10.1038/nature06901
| Summary | Full Text (HTML / PDF) |
letter
An agonist-induced conformational change in the growth hormone receptor determines the choice of signalling pathway
Scott W. Rowlinson et al.
Nature Cell Biology 10, 740–747
(June 2008); doi:10.1038/ncb1737
| Summary | Full Text (HTML / PDF) |
article
Foxo1 directly regulates the transcription of recombination-activating genes during B cell development
Rupesh H Amin & Mark S Schlissel
Nature Immunology 9, 613–622
(June 2008); doi:10.1038/ni.1612
| Summary | Full Text (HTML / PDF) |
article
SLP-65 regulates immunoglobulin light chain gene recombination through the PI(3)K–PKB–Foxo pathway
Sebastian Herzog et al.
Nature Immunology 9, 623–631
(June 2008); doi:10.1038/ni.1616
| Summary | Full Text (HTML / PDF) |
news and views
Foxos around make B cells tolerable
Marta A W Rowh & Craig H Bassing
Nature Immunology 9, 586–588
(June 2008); doi:10.1038/ni0608-586
| Full Text (HTML / PDF) |
article
Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2
Tatsukata Kawagoe et al.
Nature Immunology 9, 684–691
(June 2008); doi:10.1038/ni.1606
| Summary | Full Text (HTML / PDF) |
news and views
IRAK2 takes its place in TLR signaling
Etienne Meylan & Jürg Tschopp
Nature Immunology 9, 581–582
(June 2008); doi:10.1038/ni0608-581
| Full Text (HTML / PDF) |
May
letter
Angiogenesis selectively requires the p110α isoform of PI3K to control endothelial cell migration
Mariona Graupera et al.
Nature 453, 662–666
(29 May 2008); doi:10.1038/nature06892
| Summary | Full Text (HTML / PDF) |
letter
Single-stranded DNA-binding protein hSSB1 is critical for genomic stability
Derek J. Richard et al.
Nature 453, 677–681
(29 May 2008); doi:10.1038/nature06883
| Summary | Full Text (HTML / PDF) |
letter
HP1-β mobilization promotes chromatin changes that initiate the DNA damage response
Nabieh Ayoub, Anand D. Jeyasekharan, Juan A. Bernal & Ashok R. Venkitaraman
Nature 453, 682–686
(29 May 2008); doi:10.1038/nature06875
| Summary | Full Text (HTML / PDF) |
article
Identification of RIP1 kinase as a specific cellular target of necrostatins
Alexei Degterev et al.
Nature Chemical Biology 5, 313–321
(May 2008); doi:10.1038/nchembio.83
| Summary | Full Text (HTML / PDF) |
letter
The ground state of embryonic stem cell self-renewal
Qi-Long Ying et al.
Nature 453, 519–523
(22 May 2008); doi:10.1038/nature06968
| Summary | Full Text (HTML / PDF) |
article
Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1
Huazhang An et al.
Nature Immunology 9, 542–550
(May 2008); doi:10.1038/ni.1604
| Summary | Full Text (HTML / PDF) |
news and views
'Fine tuning' TLR signaling
Luke A J O'Neill
Nature Immunology 9, 459–461
(May 2008); doi:10.1038/ni0508-459
| Full Text (HTML / PDF) |
review
Immunobiology of the TAM receptors
Greg Lemke & Carla V. Rothline
Nature Reviews Immunology 8, 327–336
(May 2008); doi:10.1038/nri2303
| Summary | Full Text (HTML / PDF) |
article
Functional identification of sensory mechanisms required for developmental song learning
Sarah E London & David F Clayton
Nature Neuroscience 11, 579–586
(May 2008); doi:10.1038/nn.2103
| Summary | Full Text (HTML / PDF) |
news and views
Learning outside the song system
Noah Gray
Nature Neuroscience 11, 533
(May 2008); doi:10.1038/nn0508-533
| Full Text (HTML / PDF) |
review
Up on the tightrope: natural killer cell activation and inhibition
Lewis L Lanier
Nature Immunology 9, 495–502
(May 2008); doi:10.1038/ni1581
| Summary | Full Text (HTML / PDF) |
perpective
High-throughput kinase profiling as a platform for drug discovery
David M. Goldstein, Nathanael S. Gray & Patrick P. Zarrinkar
Nature Reviews Drug Discovery 7, 391–397
(May 2008); doi:10.1038/nrd2541
| Summary | Full Text (HTML / PDF) |
article
Phosphorylation of human PRP28 by SRPK2 is required for integration of the U4/U6-U5 tri-snRNP into the spliceosome
Rebecca Mathew, Klaus Hartmuth, Sina Möhlmann, Henning Urlaub, Ralf Ficner & Reinhard Lührmann
Nature Structural & Molecular Biology 14, 435–443
(May 2008); doi:10.1038/nsmb.1415
| Summary | Full Text (HTML / PDF) |
article
Kemp elimination catalysts by computational enzyme design
Daniela Röthlisberger et al.
Nature 453, 190–195
(8 May 2008); doi:10.1038/nature06879
| Summary | Full Text (HTML / PDF) |
news and views
Computational biochemistry: Old enzymes, new tricks
Giovanna Ghirlanda
Nature 453, 164–166
(8 May 2008); doi:10.1038/453164a
| Full Text (HTML / PDF) |
perspective
A new penumbra: transitioning from injury into repair after stroke
Eng H Lo
Nature Medicine 14, 497–500
(May 2008); doi:10.1038/nm1735
| Summary | Full Text (HTML / PDF) |
article
A role for ubiquitin in the spliceosome assembly pathway
Priya Bellare, Eliza C Small, Xinhua Huang, James A Wohlschlegel, Jonathan P Staley & Erik J Sontheimer
Nature Structural & Molecular Biology 14, 444–451
(May 2008); doi:10.1038/nsmb.1401
| Summary | Full Text (HTML / PDF) |
news and views
Modifications target spliceosome dynamics
Corina Maeder & Christine Guthrie
Nature Structural & Molecular Biology 14, 426–428
(May 2008); doi:10.1038/nsmb0508-426
| Full Text (HTML / PDF) |
April
letter
Functional interaction between FOXO3a and ATM regulates DNA damage response
Wen-Bin Tsai, Young Min Chung, Yoko Takahashi, Zhaohui Xu & Mickey C.-T. Hu
Nature Cell Biology 10, 460–467
(April 2008); doi:10.1038/ncb1709
| Summary | Full Text (HTML / PDF) |
letter
A bistable Rb–E2F switch underlies the restriction point
Guang Yao, Tae Jun Lee, Seiichi Mori, Joseph R. Nevins & Lingchong You
Nature Cell Biology 10, 476–482
(April 2008); doi:10.1038/ncb1711
| Summary | Full Text (HTML / PDF) |
article
TrkB kinase is required for recovery, but not loss, of cortical responses following monocular deprivation
Megumi Kaneko, Jessica L Hanover, Pamela M England & Michael P Stryker
Nature Neuroscience 11, 497–504
(April 2008); doi:10.1038/nn2068
| Summary | Full Text (HTML / PDF) |
letter
Drosophila STAT is required for directly maintaining HP1 localization and heterochromatin stability
Song Shi et al.
Nature Cell Biology 10, 489–496
(April 2008); doi:10.1038/ncb1713
| Summary | Full Text (HTML / PDF) |
review
The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy
Isabel M. Chu, Ludger Hengst & Joyce M. Slingerland
Nature Reviews Cancer 8, 253–267
(April 2008); doi:10.1038/nrc2347
| Summary | Full Text (HTML / PDF) |
letter
Phosphoregulation and depolymerization-driven movement of the Dam1 complex do not require ring formation
Daniel R. Gestaut et al.
Nature Cell Biology 10, 407–414
(April 2008); doi:10.1038/ncb1702
| Summary | Full Text (HTML / PDF) |
news and views
Dam1 complexes go it alone on disassembling microtubules
Melissa K. Gardner & David J. Odde
Nature Cell Biology 10, 379–381
(April 2008); doi:10.1038/ncb0408-379
| Full Text (HTML / PDF) |
review
Regulation of DNA repair throughout the cell cycle
Dana Branzei & Marco Foiani
Nature Reviews Molecular Cell Biology 9, 297–308
(April 2008); doi:10.1038/nrm2351
| Summary | Full Text (HTML / PDF) |
review
The TORrid affairs of viruses: effects of mammalian DNA viruses on the PI3K–Akt–mTOR signalling pathway
Nicholas J. Buchkovich, Yongjun Yu, Carisa A. Zampieri & James C. Alwine
Nature Reviews Microbiology 6, 266–275
(April 2008); doi:10.1038/nrmicro1855
| Summary | Full Text (HTML / PDF) |
letter
Tumour maintenance is mediated by eNOS
Kian-Huat Lim, Brooke B. Ancrile, David F. Kashatus & Christopher M. Counter
Nature 452, 646–649
(3 April 2008); doi:10.1038/nature06778
| Summary | Full Text (HTML / PDF) |
letter
Drosophila short neuropeptide F signalling regulates growth by ERK-mediated insulin signalling
Kyu-Sun Lee et al.
Nature Cell Biology 10, 468–475
(April 2008); doi:10.1038/ncb1710
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March
letter
Regulation of VEGF-mediated angiogenesis by the Akt/PKB substrate Girdin
Tomoya Kitamura et al.
Nature Cell Biology 10, 329–337
(March 2008); doi:10.1038/ncb1695
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article
Pyruvate kinase M2 is a phosphotyrosine-binding protein
Heather R. Christofk, Matthew G. Vander Heiden, Ning Wu, John M. Asara & Lewis C. Cantley
Nature 452, 181–186
(13 March 2008); doi:10.1038/nature06667
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letter
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Heather R. Christofk et al.
Nature 452, 230–233
(13 March 2008); doi:10.1038/nature06734
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article
Protein kinase CK2 links extracellular growth factor signaling with the control of p27Kip1 stability in the heart
Ludger Hauck et al.
Nature Medicine 14, 315–324
(March 2008); doi:10.1038/nm1729
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news and views
The weakness of a big heart
Thomas Force
Nature Medicine 14, 244–245
(March 2008); doi:10.1038/nm0308-244
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February
article
NGF-promoted axon growth and target innervation requires GITRL–GITR signaling
Gerard W O'Keeffe, Humberto Gutierrez, Pier Paolo Pandolfi, Carlo Riccardi & Alun M Davies
Nature Neuroscience 11, 135–142
(February 2008); doi:10.1038/nn2034
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article
Dual control of nuclear EIN3 by bifurcate MAPK cascades in C2H4 signalling
Sang-Dong Yoo, Young-Hee Cho, Guillaume Tena, Yan Xiong & Jen Sheen
Nature 451, 789–795
(14 February 2008); doi:10.1038/nature06543
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article
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
Jer-Yen Yang et al.
Nature Cell Biology 10, 138–148
(February 2008); doi:10.1038/ncb1676
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news and views
ERK and MDM2 prey on FOXO3a
Wensheng Yang, Nathan G. Dolloff & Wafik S. El-Deiry
Nature Cell Biology 10, 125–126
(February 2008); doi:10.1038/ncb0208-125
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letter
TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines
Ken J. Ishii et al.
Nature 451, 725–729
(7 February 2008); doi:10.1038/nature06537
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letter
Drosophila Pgc protein inhibits P-TEFb recruitment to chromatin in primordial germ cells
Kazuko Hanyu-Nakamura, Hiroko Sonobe-Nojima, Akie Tanigawa, Paul Lasko & Akira Nakamura
Nature 451, 730–733
(7 February 2008); doi:10.1038/nature06498
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letter
Dok1 mediates high-fat diet-induced adipocyte hypertrophy and obesity through modulation of PPAR-γ phosphorylation
Tetsuya Hosooka et al.
Nature Medicine 14, 188–193
(February 2008); doi:10.1038/nm1706
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article
High-content single-cell drug screening with phosphospecific flow cytometry
Peter O Krutzik, Janelle M Crane, Matthew R Clutter & Garry P Nolan
Nature Chemical Biology 4, 132–142
(February 2008); doi:10.1038/nchembio.2007.59
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scientific report
A selective PIKfyve inhibitor blocks PtdIns(3,5)P2 production and disrupts endomembrane transport and retroviral budding
Harold B J Jefferies et al.
EMBO Reports 9, 164–170
(February 2008); doi:10.1038/sj.embor.7401155
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article
'Tuning' of type I interferon-induced Jak–STAT1 signaling by calcium-dependent kinases in macrophages
Lu Wang et al.
Nature Immunology 9, 186–193
(February 2008); doi:10.1038/ni1548
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January
review
The anaplastic lymphoma kinase in the pathogenesis of cancer
Roberto Chiarle, Claudia Voena, Chiara Ambrogio, Roberto Piva & Giorgio Inghirami
Nature Reviews Cancer 8, 11–23
(January 2008); doi:10.1038/nrc2291
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letter
A quantitative analysis of kinase inhibitor selectivity
Mazen W Karaman et al.
Nature Biotechnology 26, 127–132
(January 2008); doi:10.1038/nbt1358
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perspective
Protein therapeutics: a summary and pharmacological classification
Benjamin Leader, Quentin J. Baca & David E. Golan
Nature Reviews Drug Discovery 7, 21–39
(January 2008); doi:10.1038/nrd2399
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article
Disruption of KIF17–Mint1 interaction by CaMKII-dependent phosphorylation: a molecular model of kinesin–cargo release
Laurent Guillaud, Richard Wong & Nobutaka Hirokawa
Nature Cell Biology 10, 19–29
(January 2008); doi:10.1038/ncb1665
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news and views
Motor-cargo release: CaMKII as a traffic cop
Shabeen Ally, Amber L. Jolly & Vladimir I. Gelfand
Nature Cell Biology 10, 3–5
(January 2008); doi:10.1038/ncb0108-3
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news and views
IP7 guards the CDK gate
John D York & Daniel J Lew
Nature Chemical Biology 4, 16–17
(January 2008); doi:10.1038/nchembio0108-16
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letter
Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
Wenqiang Yu et al.
Nature 451, 202–206
(10 January 2008); doi:10.1038/nature06468
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brief communication
Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2
Margarita Malakhova et al.
Nature Structural & Molecular Biology 15, 112–113
(January 2008); doi:10.1038/nsmb1347
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article
Molecular basis of cyclin–CDK–CKI regulation by reversible binding of an inositol pyrophosphate
Young-Sam Lee, Kexin Huang, Florante A Quiocho & Erin K O'Shea
Nature Chemical Biology 4, 25–32
(January 2008); doi:10.1038/nchembio.2007.52
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article
Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation
Eric Metzger et al.
Nature Cell Biology 10, 53–60
(January 2008); doi:10.1038/ncb1668
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news and views
Thrilling transcription through threonine phosphorylation
Luciano Di Croce & Ramin Shiekhattar
Nature Cell Biology 10, 5–6
(January 2008); doi:10.1038/ncb0108-5
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