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Research library: browse by date

November 2008

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The Research Library categorizes, and provides access to, all recent signaling-related research published in the Nature Publishing Group journals. The selection is deliberately broad to facilitate access to all research impacting on the signaling community. Both primary research and review articles are included, as are 'News and Views' articles.

Click here for free access to the 'Featured Articles' section, with new articles every week.

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article
Gibberellin-induced DELLA recognition by the gibberellin receptor GID1
Kohji Murase, Yoshinori Hirano, Tai-ping Sun & Toshio Hakoshima
Nature 456, 459–463
(27 November 2008); doi:10.1038/nature07519
| Summary | Full Text (HTML / PDF) |

letter
Structural basis for gibberellin recognition by its receptor GID1
Asako Shimada et al.
Nature 456, 520–523
(27 November 2008); doi:10.1038/nature07546
| Summary | Full Text (HTML / PDF) |

news and views
Plant Biology: Gibberellins close the lid
Peter Hedde
Nature 456, 455–456
(27 November 2008); doi:10.1038/456455a
| Full Text (HTML / PDF) |

letter
Lymphoid tissue genesis induced by commensals through NOD1 regulates intestinal homeostasis
Djahida Bouskra et al.
Nature 456, 507–510
(27 November 2008); doi:10.1038/nature07450
| Summary | Full Text (HTML / PDF) |

letter
Sarcolemma-localized nNOS is required to maintain activity after mild exercise
Yvonne M. Kobayashi et al.
Nature 456, 511–515
(27 November 2008); doi:10.1038/nature07414
| Summary | Full Text (HTML / PDF) |

letter
A fast, robust and tunable synthetic gene oscillator
Jesse Stricker et al.
Nature 456, 516–519
(27 November 2008); doi:10.1038/nature07389
| Summary | Full Text (HTML / PDF) |

letter
53BP1 promotes non-homologous end joining of telomeres by increasing chromatin mobility
Nadya Dimitrova, Yi-Chun M. Chen, David L. Spector & Titia de Lange
Nature 456, 524–528
(27 November 2008); doi:10.1038/nature07433
| Summary | Full Text (HTML / PDF) |

letter
53BP1 facilitates long-range DNA end-joining during V(D)J recombination
Simone Difilippantonio et al.
Nature 456, 529–533
(27 November 2008); doi:10.1038/nature07476
| Summary | Full Text (HTML / PDF) |

letter
The S100A8–serum amyloid A3–TLR4 paracrine cascade establishes a pre-metastatic phase
Sachie Hiratsuka et al.
Nature Cell Biology 10, 1349–1355
(November 2008); doi:10.1038/ncb1794
| Summary | Full Text (HTML / PDF) |

letter
Scaffolding function of PAK in the PDK1–Akt pathway
Maiko Higuchi, Keisuke Onishi, Chikako Kikuchi & Yukiko Gotoh
Nature Cell Biology 10, 1356–1364
(November 2008); doi:10.1038/ncb1795
| Summary | Full Text (HTML / PDF) |

review
From cells to organs: building polarized tissue
David M. Bryant & Keith E. Mostov
Nature Reviews Molecular Cell Biology 9, 887–901
(November 2008); doi:10.1038/nrm2523
| Summary | Full Text (HTML / PDF) |

article
The immunity-related GTPase Irgm1 promotes the expansion of activated CD4+ T cell populations by preventing interferon-γ-induced cell death
Carl G Feng et al.
Nature Immunology 9, 1279–1287
(November 2008); doi:10.1038/ni.1653
| Summary | Full Text (HTML / PDF) |

news and views
IFN-γ and self-absorbed CD4+ T cells: a regulatory double negative
David Hildeman & Edith Janssen
Nature Immunology 9, 1210–1212
(November 2008); doi:10.1038/ni1108-1210
| Full Text (HTML / PDF) |

review
Mammalian glycosylation in immunity
Jamey D. Marth & Prabhjit K. Grewal
Nature Reviews Immunology 8, 874–887
(November 2008); doi:10.1038/nri2417
| Summary | Full Text (HTML / PDF) |

article
5'-triphosphate-siRNA: turning gene silencing and Rig-I activation against melanoma
Hendrik Poeck et al.
Nature Medicine 14, 1256–1263
(November 2008); doi:10.1038/nm.1887
| Summary | Full Text (HTML / PDF) |

news and views
RIG-ing an antitumor response
Fabio Petrocca & Judy Lieberman
Nature Medicine 14, 1152–1153
(November 2008); doi:10.1038/nm1108-1152
| Full Text (HTML / PDF) |

letter
The miR-15a—miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities
Désirée Bonci et al.
Nature Medicine 14, 1271–1277
(November 2008); doi:10.1038/nm.1880
| Summary | Full Text (HTML / PDF) |

review
Derailed endocytosis: an emerging feature of cancer
Yaron Mosesson, Gordon B. Mills & Yosef Yarden
Nature Reviews Cancer 8, 835–850
(November 2008); doi:10.1038/nrc2521
| Summary | Full Text (HTML / PDF) |

article
Structure and function of a transcriptional network activated by the MAPK Hog1
Andrew P Capaldi et al.
Nature Genetics 40, 1300–1306
(November 2008); doi:10.1038/ng.235
| Summary | Full Text (HTML / PDF) |

review
Biological principles of microRNA-mediated regulation: shared themes amid diversity
Alex S. Flynt & Eric C. Lai
Nature Reviews Genetics 9, 831–842
(November 2008); doi:10.1038/nrg2455
| Summary | Full Text (HTML / PDF) |

perspective
Dynamic Notch signaling in neural progenitor cells and a revised view of lateral inhibition
Ryoichiro Kageyama, Toshiyuki Ohtsuka, Hiromi Shimojo & Itaru Imayoshi
Nature Neuroscience 11, 1247–1251
(November 2008); doi:10.1038/nn.2208
| Summary | Full Text (HTML / PDF) |

review
Ubiquitin, the proteasome and protein degradation in neuronal function and dysfunction
Hwan-Ching Tai & Erin M. Schuman
Nature Reviews Neuroscience 9, 826–838
(November 2008); doi:10.1038/nrn2499
| Summary | Full Text (HTML / PDF) |

article
A quantitative model of transcription factor–activated gene expression
Harold D Kim & Erin K O'Shea
Nature Structural & Molecular Biology 15, 1192–1198
(November 2008); doi:10.1038/nsmb.1500
| Summary | Full Text (HTML / PDF) |

article
Insights into interferon regulatory factor activation from the crystal structure of dimeric IRF5
Weijun Chen et al.
Nature Structural & Molecular Biology 15, 1213–1220
(November 2008); doi:10.1038/nsmb.1496
| Summary | Full Text (HTML / PDF) |

article
A nano-positioning system for macromolecular structural analysis
Adam Muschielok et al.
Nature Methods 5, 965–971
(November 2008); doi:10.1038/nmeth.1259
| Summary | Full Text (HTML / PDF) |

review
Targeting and tinkering with interaction networks
Robert B Russell & Patrick Aloy
Nature Chemical Biology 4, 666–673
(November 2008); doi:10.1038/nchembio.119
| Summary | Full Text (HTML / PDF) |

article
Structure of the intact PPAR-γ–RXR-α nuclear receptor complex on DNA
Vikas Chandra et al.
Nature 456, 350–356
doi:10.1038/nature07413
| Summary | Full Text (HTML / PDF) |

letter
Concerted multi-pronged attack by calpastatin to occlude the catalytic cleft of heterodimeric calpains
Tudor Moldoveanu, Kalle Gehring & Douglas R. Green
Nature 456, 404–408
(20 November 2008); doi:10.1038/nature07353
| Summary | Full Text (HTML / PDF) |

letter
Calcium-bound structure of calpain and its mechanism of inhibition by calpastatin
Rachel A. Hanna, Robert L. Campbell & Peter L. Davies
Nature 456, 409–412
(20 November 2008); doi:10.1038/nature07451
| Summary | Full Text (HTML / PDF) |

news and views
Structural biology: Enzyme knocked for a loop
Ronald L. Mellgren
Nature 456, 337–338
(20 November 2008); doi:10.1038/456337a
| Full Text (HTML / PDF) |

article
KIF1Bβ- and KIF1A-mediated axonal transport of presynaptic regulator Rab3 occurs in a GTP-dependent manner through DENN/MADD
Shinsuke Niwa, Yosuke Tanaka & Nobutaka Hirokawa
Nature Cell Biology 10, 1269-1279 (2008)
(November 2008); doi:10.1038/ncb1785
| Summary | Full Text (HTML / PDF) |

letter
IAPs contain an evolutionarily conserved ubiquitin-binding domain that regulates NF-κB as well as cell survival and oncogenesis
Mads Gyrd-Hansen et al.
Nature Cell Biology 10, 1309-1317 (2008)
(November 2008); doi:10.1038/ncb1789
| Summary | Full Text (HTML / PDF) |

review
Crosstalk between small GTPases and polarity proteins in cell polarization
Sandra Iden & John G. Collard
Nature Reviews Molecular Cell Biology 9, 846–859
(November 2008); doi:10.1038/nrm2521
| Summary | Full Text (HTML / PDF) |

article
The actin regulator coronin 1A is mutant in a thymic egress–deficient mouse strain and in a patient with severe combined immunodeficiency
Lawrence R Shiow et al.
Nature Immunology 9, 1307–1315
(November 2008); doi:10.1038/ni.1662
| Summary | Full Text (HTML / PDF) |

news and views
Immunodeficiency: when T cells are stuck at home
Kristin A Hogquist
Nature Immunology 9, 1207–1208
(November 2008); doi:10.1038/ni1108-1207
| Full Text (HTML / PDF) |

review
Cross-regulation between herpesviruses and the TNF superfamily members
John R. Šedý, Patricia G. Spear & Carl F. Ware
Nature Reviews Immunology 8, 861–873
(November 2008); doi:10.1038/nri2434
| Summary | Full Text (HTML / PDF) |

article
Opposing effects of HLA class I molecules in tuning autoreactive CD8+ T cells in multiple sclerosis
Manuel A Friese et al.
Nature Medicine 14, 1227–1235
(November 2008); doi:10.1038/nm.1881
| Summary | Full Text (HTML / PDF) |

news and views
HLA class I: friend and foe of multiple sclerosis
Roland Martin
Nature Medicine 14, 1150–1151
(November 2008); doi:10.1038/nm1108-1150
| Full Text (HTML / PDF) |

perspective
Ageing, oxidative stress and cancer: paradigms in parallax
Christopher C. Benz & Christina Yau
Nature Reviews Cancer 8, 875–879
(November 2008); doi:10.1038/nrc2522
| Summary | Full Text (HTML / PDF) |

perspective
Cytokines and their relationship to the symptoms and outcome of cancer
Bostjan Seruga, Haibo Zhang, Lori J. Bernstein & Ian F. Tannock
Nature Reviews Cancer 8, 887–899
(November 2008); doi:10.1038/nrc2507
| Summary | Full Text (HTML / PDF) |

letter
Tbc1d1 mutation in lean mouse strain confers leanness and protects from diet-induced obesity
Alexandra Chadt et al.
Nature Genetics 40, 1354–1359
(November 2008); doi:10.1038/ng.244
| Summary | Full Text (HTML / PDF) |

review
Epistasis — the essential role of gene interactions in the structure and evolution of genetic systems
Patrick C. Phillips
Nature Reviews Genetics 9, 855–867
(November 2008); doi:10.1038/nrg2452
| Summary | Full Text (HTML / PDF) |

article
β-catenin is required for memory consolidation
Kimberly A Maguschak & Kerry J Ressler
Nature Neuroscience 11, 1319–1326
(November 2008); doi:10.1038/nn.2198
| Summary | Full Text (HTML / PDF) |

review
Present and future drug treatments for chronic kidney diseases: evolving targets in renoprotection
Norberto Perico, Ariela Benigni & Giuseppe Remuzzi
Nature Reviews Drug Discovery 7, 936–953
(November 2008); doi:10.1038/nrd2685
| Summary | Full Text (HTML / PDF) |

article
The Janus-faced nature of the C2B domain is fundamental for synaptotagmin-1 function
Mingshan Xue, Cong Ma, Timothy K Craig, Christian Rosenmund & Josep Rizo
Nature Structural & Molecular Biology 15, 1160–1168
(November 2008); doi:10.1038/nsmb.1508
| Summary | Full Text (HTML / PDF) |

article
Phosphorylation of APOBEC3G by protein kinase A regulates its interaction with HIV-1 Vif
Kotaro Shirakawa et al.
Nature Structural & Molecular Biology 15, 1184–1191
(November 2008); doi:10.1038/nsmb.1497
| Summary | Full Text (HTML / PDF) |

review
Avoiding the void: cell-to-cell spread of human viruses
Quentin Sattentau
Nature Reviews Microbiology 6, 815–826
(November 2008); doi:10.1038/nrmicro1972
| Summary | Full Text (HTML / PDF) |

brief communication
High-speed, miniaturized fluorescence microscopy in freely moving mice
Benjamin A Flusberg et al.
Nature Methods 5, 935–938
(November 2008); doi:10.1038/nmeth.1256
| Summary | Full Text (HTML / PDF) |

news and views
New views into the brain of mice on the move
Fritjof Helmchen & Carl C H Petersen
Nature Methods 5, 925–926
(November 2008); doi:10.1038/nmeth1108-925
| Full Text (HTML / PDF) |

perspective
Learning biological networks: from modules to dynamics
Richard Bonneau
Nature Chemical Biology 4, 658–664
(November 2008); doi:10.1038/nchembio.122
| Summary | Full Text (HTML / PDF) |

commentary
Reverse engineering intracellular biochemical networks
Eli Zamir & Philippe I H Bastiaens
Nature Chemical Biology 4, 643–647
(November 2008); doi:10.1038/nchembio1108-643
| Summary | Full Text (HTML / PDF) |

article
Deconstructing voltage sensor function and pharmacology in sodium channels
Frank Bosmans, Marie-France Martin-Eauclaire & Kenton J. Swartz
Nature 456, 202–208
(13 November 2008); doi:10.1038/nature07473
| Summary | Full Text (HTML / PDF) |

news and views
Ion channels: The voltage-sensor quartet
J. R. Bankston & R. S. Kass
Nature 456, 183–185
(November 2008); doi:10.1038/456183a
| Full Text (HTML / PDF) |

article
Structure of the guide-strand-containing argonaute silencing complex
Yanli Wang, Gang Sheng, Stefan Juranek, Thomas Tuschl & Dinshaw J. Patel
Nature 456, 209–213
(13 November 2008); doi:10.1038/nature07315
| Summary | Full Text (HTML / PDF) |

letter
A key role for autophagy and the autophagy gene Atg16l1 in mouse and human intestinal Paneth cells
Ken Cadwell et al.
Nature 456, 259–263
(13 November 2008); doi:10.1038/nature07416
| Summary | Full Text (HTML / PDF) |

letter
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
Tatsuya Saitoh et al.
Nature 456, 264–268
(13 November 2008); doi:10.1038/nature07383
| Summary | Full Text (HTML / PDF) |

letter
A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange
Yi Liu et al.
Nature 456, 269–273
(13 November 2008); doi:10.1038/nature07349
| Summary | Full Text (HTML / PDF) |

letter
Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways
Kyoko Arimoto, Hiroyuki Fukuda, Shinobu Imajoh-Ohmi, Haruo Saito & Mutsuhiro Takekawa
Nature Cell Biology 10, 1324–1332
(November 2008); doi:10.1038/ncb1791
| Summary | Full Text (HTML / PDF) |

article
Planar polarization in embryonic epidermis orchestrates global asymmetric morphogenesis of hair follicles
Danelle Devenport & Elaine Fuchs
Nature Cell Biology 10, 1257–1268
(November 2008) doi:10.1038/ncb1784
| Summary | Full Text (HTML / PDF) |

news and views
Bad hair days for mouse PCP mutants
Jeffrey D. Axelrod
Nature Cell Biology 10, 1251–1253
(November 2008); doi:10.1038/ncb1108-1251
| Full Text (HTML / PDF) |

perspective
Turning anti-ageing genes against cancer
Valter D. Longo, Michael R. Lieber & Jan Vijg
Nature Reviews Molecular Cell Biology 9, 903–910
(November 2008); doi:10.1038/nrm2526
| Summary | Full Text (HTML / PDF) |

article
CEACAM1 inhibits Toll-like receptor 2–triggered antibacterial responses of human pulmonary epithelial cells
Hortense Slevogt et al.
Nature Immunology 9, 1270–1278
(November 2008); doi:10.1038/ni.1661
| Summary | Full Text (HTML / PDF) |

article
Triggering the succinate receptor GPR91 on dendritic cells enhances immunity
Tina Rubic et al.
Nature Immunology 9, 1261–1269
(November 2008); doi:10.1038/ni.1657
| Summary | Full Text (HTML / PDF) |

review
TRIM family proteins and their emerging roles in innate immunity
Keiko Ozato, Dong-Mi Shin, Tsung-Hsien Chang & Herbert C. Morse, III
Nature Reviews Immunology 8, 849–860
(November 2008); doi:10.1038/nri2413
| Summary | Full Text (HTML / PDF) |

article
Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangioma
Masatoshi Jinnin et al.
Nature Medicine 14, 1236–1246
(November 2008); doi:10.1038/nm.1877
| Summary | Full Text (HTML / PDF) |

news and views
Healing hemangiomas
Lena Claesson-Welsh
Nature Medicine 14, 1147–1148
(November 2008); doi:10.1038/nm1108-1147
| Full Text (HTML / PDF) |

review
The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer
William G. Kaelin Jr
Nature Reviews Cancer 8, 865–873
(November 2008); doi:10.1038/nrc2502
| Summary | Full Text (HTML / PDF) |

article
Functional organization of the transcriptome in human brain
Michael C Oldham et al.
Nature Neuroscience 11, 1271–1282
(November 2008); doi:10.1038/nn.2207
| Summary | Full Text (HTML / PDF) |

news and views
What is in the brain soup?
Károly Mirnics
Nature Neuroscience 11, 1237–1238
(November 2008); doi:10.1038/nn1108-1237
| Full Text (HTML / PDF) |

research
Induction of pluripotent stem cells from primary human fibroblasts with only Oct4 and Sox2
Danwei Huangfu et al.
Nature Biotechnology 26, 1269–1275
(November 2008); doi:10.1038/nbt.1502
| Summary | Full Text (HTML / PDF) |

news and views
The many ways to make an iPS cell
William E Lowry & Kathrin Plath
Nature Biotechnology 26, 1246–1248
(November 2008); doi:10.1038/nbt1108-1246
| Full Text (HTML / PDF) |

article
FANCI phosphorylation functions as a molecular switch to turn on the Fanconi anemia pathway
Masamichi Ishiai et al.
Nature Structural & Molecular Biology 15, 1138–1146
(November 2008); doi:10.1038/nsmb.1504
| Summary | Full Text (HTML / PDF) |

news and views
A major switch for the Fanconi anemia DNA damage–response pathway
Weidong Wang
Nature Structural & Molecular Biology 15, 1128–1130
(November 2008); doi:10.1038/nsmb1108-1128
| Full Text (HTML / PDF) |

article
The H3K36 demethylase Jhdm1b/Kdm2b regulates cell proliferation and senescence through p15Ink4b
Jin He, Eric M Kallin, Yu-ichi Tsukada & Yi Zhang
Nature Structural & Molecular Biology 15, 1169–1175
(November 2008); doi:10.1038/nsmb.1499
| Summary | Full Text (HTML / PDF) |

news and views
An INKlination for epigenetic control of senescence
Gordon Peters
Nature Structural & Molecular Biology 15, 1133–1134
(November 2008); doi:10.1038/nsmb1108-1133
| Full Text (HTML / PDF) |

article
Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases
Beth Apsel et al.
Nature Chemical Biology 4, 691–699
(November 2008); doi:10.1038/nchembio.117
| Summary | Full Text (HTML / PDF) |

news and views
Killing two kinase families with one stone
Benoit Bilanges, Neil Torbett & Bart Vanhaesebroeck
Nature Chemical Biology 4, 648–649
(November 2008); doi:10.1038/nchembio1108-648
| Full Text (HTML / PDF) |

article
Accurate whole human genome sequencing using reversible terminator chemistry
David R. Bentley et al.
Nature 456, 53–59
(6 November 2008); doi:10.1038/nature07517
| Summary | Full Text (HTML / PDF) |

article
DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome
Timothy J. Ley et al.
Nature 456, 66–72
(6 November 2008); doi:10.1038/nature07485
| Summary | Full Text (HTML / PDF) |

news and views
Human genetics: Individual genomes diversify
Samuel Levy & Robert L. Strausberg
Nature 456, 49–51
(November 2008); doi:10.1038/456049a
| Full Text (HTML / PDF) |

letter
Molecular basis of xeroderma pigmentosum group C DNA recognition by engineered meganucleases
Pilar Redondo et al.
Nature 456, 107–111
(6 November 2008); doi:10.1038/nature07343
| Summary | Full Text (HTML / PDF) |

letter
The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers
Aubin Penna et al.
Nature 456, 116–120
(6 November 2008); doi:10.1038/nature07338
| Summary | Full Text (HTML / PDF) |

letter
Histone H2A.Z and DNA methylation are mutually antagonistic chromatin marks
Daniel Zilberman, Devin Coleman-Derr, Tracy Ballinger & Steven Henikoff
Nature 456, 125–129
(6 November 2008); doi:10.1038/nature07324
| Summary | Full Text (HTML / PDF) |

letter
Stepwise chromatin remodelling by a cascade of transcription initiation of non-coding RNAs
Kouji Hirota, Tomoichiro Miyoshi, Kazuto Kugou, Charles S. Hoffman, Takehiko Shibata & Kunihiro Ohta
Nature 456, 130–134
(6 November 2008); doi:10.1038/nature07348
| Summary | Full Text (HTML / PDF) |

review
Coordinated protein sorting, targeting and distribution in polarized cells
Ira Mellman & W. James Nelson
Nature Reviews Molecular Cell Biology 9, 833–845
(November 2008); doi:10.1038/nrm2525
| Summary | Full Text (HTML / PDF) |

perspective
Cyclin-dependent kinases and cell-cycle transitions: does one fit all?
Helfrid Hochegger, Shunichi Takeda & Tim Hunt
Nature Reviews Molecular Cell Biology 9, 910–916
(November 2008); doi:10.1038/nrm2510
| Summary | Full Text (HTML / PDF) |

article
Modulation of the antitumor immune response by complement
Maciej M Markiewski et al.
Nature Immunology 9, 1225–1235
(November 2008); doi:10.1038/ni.1655
| Summary | Full Text (HTML / PDF) |

news and views
Cancer exploiting complement: a clue or an exception?
Bruce E Loveland & Jonathan Cebon
Nature Immunology 9, 1205–1206
(November 2008); doi:10.1038/ni1108-1205
| Full Text (HTML / PDF) |

article
Priming for T helper type 2 differentiation by interleukin 2—mediated induction of interleukin 4 receptor α-chain expression
Wei Liao et al.
Nature Immunology 9, 1288–1296
(November 2008); doi:10.1038/ni.1656
| Summary | Full Text (HTML / PDF) |

article
Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells
Fuping Zhang, Guangxun Meng & Warren Strober
Nature Immunology 9, 1297–1306
(November 2008); doi:10.1038/ni.1663
| Summary | Full Text (HTML / PDF) |

review
New regulators of NF-κB in inflammation
Sankar Ghosh & Matthew S. Hayden
Nature Reviews Immunology 8, 837–848
(November 2008); doi:10.1038/nri2423
| Summary | Full Text (HTML / PDF) |

review
Hypoxia signalling through mTOR and the unfolded protein response in cancer
Bradly G. Wouters & Marianne Koritzinsky
Nature Reviews Cancer 8, 851–864
(November 2008); doi:10.1038/nrc2501
| Summary | Full Text (HTML / PDF) |

perspective
VEGF-A splicing: the key to anti-angiogenic therapeutics?
Steven J. Harper & David O. Bates
Nature Reviews Cancer 8, 880–887
(November 2008); doi:10.1038/nrc2505
| Summary | Full Text (HTML / PDF) |

article
Lgr5 marks cycling, yet long-lived, hair follicle stem cells
Viljar Jaks et al.
Nature Genetics 40, 1291–1306
(November 2008); doi:10.1038/ng.239
| Summary | Full Text (HTML / PDF) |

news and views
A glorious revolution in stem cell biology
Bruce A Morgan
Nature Genetics 40, 1269–1270
(November 2008); doi:10.1038/ng1108-1269
| Full Text (HTML / PDF) |

review
Metabolic syndrome: from epidemiology to systems biology
Aldons J. Lusis, Alan D. Attie & Karen Reue
Nature Reviews Genetics 9, 819–830
(November 2008); doi:10.1038/nrg2468
| Summary | Full Text (HTML / PDF) |

article
Phospholipase A2 reduction ameliorates cognitive deficits in a mouse model of Alzheimer's disease
Rene O Sanchez-Mejia et al.
Nature Neuroscience 11, 1311–1318
(November 2008); doi:10.1038/nn.2213
| Summary | Full Text (HTML / PDF) |

review
Silent synapses and the emergence of a postsynaptic mechanism for LTP
Geoffrey A. Kerchner & Roger A. Nicoll
Nature Reviews Neuroscience 9, 813–825
(November 2008); doi:10.1038/nrn2501
| Summary | Full Text (HTML / PDF) |

review
Novel therapeutic applications of cardiac glycosides
Ioannis Prassas & Eleftherios P. Diamandis
Nature Reviews Drug Discovery 7, 926–935
(November 2008); doi:10.1038/nrd2682
| Summary | Full Text (HTML / PDF) |

article
Decision tree–driven tandem mass spectrometry for shotgun proteomics
Danielle L Swaney, Graeme C McAlister & Joshua J Coon
Nature Methods 5, 959–964
(November 2008); doi:10.1038/nmeth.1260
| Summary | Full Text (HTML / PDF) |

article
Cortisone dissociates the Shaker family K+ channels from their β subunits
Yaping Pan et al.
Nature Chemical Biology 4, 708–714
(November 2008); doi:10.1038/nchembio.114
| Summary | Full Text (HTML / PDF) |

news and views
To dislodge an enzyme from an ion channel, try steroids
Susy C Kohout & Ehud Y Isacoff
Nature Chemical Biology 4, 650–651
(November 2008); doi:10.1038/nchembio1108-650
| Full Text (HTML / PDF) |

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